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Drugs impair keratinocyte DNA repair in culture.(Clinical Rounds)

Publication: Skin & Allergy News

Publication Date: 01-JUL-05

Author: Wendling, Patrice
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COPYRIGHT 2005 International Medical News Group

VIENNA -- Cyclosporine and ascomycin decreased DNA repair and reduced apoptosis in human keratinocyte cultures exposed to ultraviolet B light, Daniel B. Yarosh, Ph.D., reported at the 10th World Congress on Cancers of the Skin.

Dr. Yarosh called this finding "hypothesis generating" and said the observation may explain in part why skin cancers occur within 10 years in about 35% of patients who undergo renal transplant.

Dr. Yarosh is president of AGI Dermatics, a biomolecular research company based in Freeport, N.Y., which is developing Dimericine, an...

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