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Resistant infections tied to worsened outcomes.(Clinical Rounds)

Publication: Skin & Allergy News

Publication Date: 01-SEP-05

Author: Splete, Heidi
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COPYRIGHT 2005 International Medical News Group

BETHESDA, MD. -- Evidence suggests that multidrug-resistant gram-negative organisms contribute to worse patient outcomes if patients are not severely ill, Arjun Srinivasan, M.D., said at an annual conference on antimicrobial resistance sponsored by the National Foundation for Infectious Diseases.

"When you factor severity of illness, extremely severe illness overrides the impact of multidrug resistance on mortality," Dr. Srinivasan said in an interview.

In some studies of patients with gram-negative infections, multidrug resistance was not associated with significantly higher all-cause mortality. But many outcome studies in this research area have not differentiated between...

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