AccessMyLibrary provides FREE access to over 30 million articles from top publications available through your library.
Create a link to this page
Copy and paste this link tag into your Web page or blog:
Overcoming GI stasis: new fast-dissolving sumatriptan relieves migraine.(Clinical Rounds)
RANCHO MIRAGE, CALIF. -- A new rapid-release formulation of sumatriptan has proved superior to placebo at relieving migraines within 2 hours when taken early in the attack, according to the findings of a randomized, double-blind, multicenter trial.
This formulation was developed for improved gastric disintegration and dispersion in order to overcome the gastrointestinal stasis that occurs with many migraine attacks. It has been available in the United States since January, Diane Boswell said at a meeting sponsored by the Diamond Headache Clinic.
In an intention-to-treat analysis, 66% of the patients who took 100 mg of the new formulation while their pain was still mild were pain free within 2 hours, compared with 51% of patients taking a 50-mg dose and 20% of patients taking the placebo. All differences were statistically significant.
This compares favorably with the action of conventional sumatriptan tablets, said Ms. Boswell, of the department of clinical development and medical affairs at Glaxo-SmithKline UK, which sponsored the study.
A total of 432 patients ...
- FDA ADVISES DOCTORS TO STOP USING 100 MG DOSE OF MANOPLAX
- Press release article from: PR Newswire April 26, 1993 700+ words
...significantly increased risk of death in patients taking 100 mg. of the drug. Increased mortality has not been seen in patients given 75 mg. of the drug, and both...50 mg. doses may still be used. Patients on Manoplax should not alter their...
- Sitaxsentan proves effective in pulmonary arterial hypertension: the phase III...
- Magazine article from: Family Practice News Goldman, Bruce August 15, 2005 700+ words
...functional class in patients with pulmonary arterial...Exercise) was a 246-patient, 18-week, randomized...the world, about 60 patients were randomized to once...commonly prescribed for PAH patients. Sitaxsentan inhibits...same number of per-patient warfarin dose adjustments...
- WYETH-AYERST LABORATORIES' LODINE(R) (ETODOLAC) RECEIVES NEW RHEUMATOID...
- Press release article from: Business Wire July 2, 1996 700+ words
...multicenter clinical trial involving 1,446 patients with active RA. Data from the study...were efficacious and well tolerated in patients being treated for active rheumatoid arthritis...physicians with a new option for managing patients with arthritis symptoms," Dr. Deitch...
- Bristol-Myers Squibb Announces U.S. Food And Drug Administration Approval Of...
- Press release article from: PR Newswire April 14, 2003 700+ words
...another option for doctors and their patients to help manage this disease. Glucophage...kidneys are not functioning properly. Patients should advise their doctor about...as this will increase the risk. Patients should not take these drugs if they...
- Schering-Plough To Make 20-mg Dose.
- Magazine article from: BIOWORLD Today Deal, Santarus Gets As Much As $80m In Otc Zegerid October 23, 2006 700+ words
...Schering-Plough will develop, make and sell Zegerid at the 20-mg dose, which likely will require "some type of clinical trials...Doctors write more than 95 percent of prescriptions for the 40-mg dose, Proehl said, a trend "in line with other PPI drugs available...
- Safety and pharmacokinetics of famciclovir single 1500 mg dose in adolescents...
- Magazine article from: Journal of Drugs in Dermatology June 1, 2009 700+ words
...study will assess the safety, tolerability of a single 1500 mg dose of famciclovir in 50 adolescents with recurrent herpes labialis...pharmacokinetics (PK) assessment of famciclovir single 1500 mg dose. Inclusion criteria is as follows: Outpatient males or females...
- Alexza's AZ-104 (Staccato(R) Loxapine) Phase 2a Trial Meets Primary Endpoint of...
- Press release article from: PR Newswire March 3, 2008 700+ words
...severe intensity. Patients stayed in the...monitored via patient diary for the...enrolled 168 patients: 43 patients in the 1.25 mg dose group, 43 patients...in which a patient has a post...with 30% of patients achieving pain...at the 2.5 mg dose (p ...
- New Analysis Shows That Intensive Lipitor Therapy Cuts the Risk of...
- Press release article from: PR Newswire February 7, 2007 700+ words
...heart failure compared to patients taking the 10 mg dose of Lipitor, according...was 2.4 percent in patients who took Lipitor 80 mg dose and 3.3 percent in...patients who took the 10 mg dose. * In patients without a history of...