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SSRIs plus migraine medications: few data for serotonin syndrome precaution.(Clinical Rounds)
RANCHO MIRAGE, CALIF. -- The fear that combining migraine medication with selective serotonin reuptake inhibitors can increase the risk of serotonin syndrome may be over-stated, Dr. Stewart J. Tepper said at a meeting sponsored by the Diamond Headache Clinic.
This concern, if unfounded, may actually be harming patients because depression, anxiety, and migraine often occur together, and many patients could benefit from taking a selective serotonin reuptake inhibitor (SSRI) and a triptan, said Dr. Tepper, director of the New England Center for Headache, Stamford, Conn.
Serotonin syndrome results from serotonin toxicity associated with use of SSRIs. The symptoms include altered mental status, autonomic dysregulation manifested as changes in vasomotor function and altered vital signs, and neuromuscular changes such as myoclonus, ataxia, and seizures, said Dr. Tepper, also of Yale University, New Haven.
The Food and Drug Administration cautions against the simultaneous use of triptans or ergots with SSRIs, based on anecdotal reports of serotonin syndrome occurring in a few patients who combined those ...
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...inhibitor can lead to serotonin syndrome, according to...migraine; and SSRIs and SNRIs, used...receiving reports of serotonin syndrome in patients who...The symptoms of serotonin syndrome, a potentially...FDA-approved SSRIs. Duloxetine...
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...evidence of developing serotonin syndrome due to drug interactions...signs or symptoms of serotonin syndrome, the investigators...adults who received SSRIs and linezolid were matched...patients who received SSRIs and non-linezolid...
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- Magazine article from: Clinical Psychiatry News Sherman, Carl November 1, 2006 700+ words
...increase blood levels of certain tricyclic antidepressants, SSRIs, and benzodiazepines, as well as phenytoin. Herbs may...side a drug that has the same action, Dr. Ernst observed. Serotonin syndrome has been reported in patients who used both St. John's...
Source: HighBeam Research, SSRIs plus migraine medications: few data for serotonin syndrome...