In addition to its primary use as an antiepileptic agent, valproic acid (Depakene, Depakote) has been used as monotherapy or combined with lithium (Lithobid), carbamazepine (Tegretol) or antipsychotics in the treatment of manic episodes associated with bipolar disorder. Drug interaction with valproic acid is commonly reported, secondary to its ability to inhibit drug elimination, (1) as well as induction of its metabolism by concurrently administered drugs. The carbapenem antibiotics have been reported to interact with valproic acid, resulting in lower valproic acid concentrations and loss of seizure control.
The following case reported the occurrence of acute seizures as a result of potential interaction between valproic acid and meropenem (Merrem), an antibiotic primarily used for treatment of intra-abdominal infections and meningitis.
Case report (2)
A 21-year-old female patient was evaluated in the …