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<a href="http://www.accessmylibrary.com/coms2/summary_0286-9183462_ITM" title="Facts and information about KAINIC-ACID-INDUCED NEURODEGENERATION: PROTECTIVE MECHANISMS OF NITRONE ANTIOXIDANTS.">KAINIC-ACID-INDUCED NEURODEGENERATION: PROTECTIVE MECHANISMS OF NITRONE ANTIOXIDANTS.</a>
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KAINIC-ACID-INDUCED NEURODEGENERATION: PROTECTIVE MECHANISMS OF NITRONE ANTIOXIDANTS.
This (Oklahoma Medical Research Foundation) research focuses on developing nitrone-based antioxidants as antidotes against chemical agents that induce excitatory neurotoxicity. It is proposed to use kainic acid, an analog of the excitatory amino acid glutamate, to induce chronic neurological damage in adult rats. This model has been widely used as a model for studying human temporal lobe epilepsy. The delayed neuronal degeneration induced by kainic acid resembles CNS neuronal injury, repair, and plasticity.
Preliminary observations show that nitrone antioxidants -- free radical trapping compounds -- protect rats from kainic-acid-induced death. It is found that cotreatment with the experimental antioxidant phenyl-N- tert-butylnitrone (PBN) results in: diminution of ...
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