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BRAIN MITOCHONDRIA: PRO-APOPTOTIC CHANGES AFTER TOXIN EXPOSURE.
Mitochondria normally function to provide sources of energy for vital cellular functions; however, under stressful conditions these organelles may trigger events that lead eventually to cell death. Thus, mitochondria have been implicated as major contributors to neuronal death in a variety of neurodegenerative disorders. This (University of Miami) report describes functional changes in mitochondria measured in living brain tissue as a result of exposure to toxins thought to contribute to neurodegeneration. Mitochondrial NADH levels are shown to increase following treatment with 1-methyl-4-phenylpyridium (MPP+) at times when neuronal electrophysiology is impaired. In addition, MPP+ appears to cause oxidation of cytochrome b, providing further support ...
- Mitochondrial NADH- or NADPH-linked aquacobalamin reductase activity is low in...
- Magazine article from: The Journal of Nutrition Watanabe, Fumio; Saido, Hisako; Yamaji, Ryoichi; Miyatake, Kazutaka; et al December 1, 1996 700+ words
Mitochondrial NADH- or NADPH-Linked Aquacobalamin...et al. 1992a and 1992b). The mitochondrial NADH- and NADPH-linked AR are...6.6 and 7.5 were used for mitochondrial NADH- and NADPH-linked, and microsomal...
- Investigators at Bar-Ilan University target ischemia.
- Magazine article from: Stem Cell Week December 29, 2008 700+ words
...damage to the spinal cord tissue. Mitochondrial NADH redox state is the most sensitive...laser Doppler flowmetry, and the mitochondrial NADH fluorescence using the fluorometric...decreased, in both experimental models, mitochondrial NADH was elevated, while reperfusion...
- Recent findings in hemorrhage described by researchers from Bar-Ilan University.
- Newspaper article from: Blood Weekly December 11, 2008 700+ words
...microcirculatory blood flow (TBF) and mitochondrial NADH in the urethral wall was used in...We hypothesized that changes in mitochondrial NADH and TBF are associated with impaired...invasive Real Time Monitoring of mitochondrial NADH and tissue blood flow in the urethral...
- Researchers from University of Tokyo publish findings in enzyme...
- Newspaper article from: Biotech Week October 29, 2008 700+ words
...Platinum nanoparticles have an activity similar to mitochondrial NADH:ubiquinone oxidoreductase,' are discussed in a new...B (Platinum nanoparticles have an activity similar to mitochondrial NADH:ubiquinone oxidoreductase. Colloids and Surfaces B...
- Kyoto University publishes research in enzyme research.(Report)
- Newspaper article from: Biotech Week May 20, 2009 700+ words
...mitochondrial functions." "This study demonstrates that the mitochondrial NADH kinase reaction is dispensable as a source of mitochondrial...kinase reaction. The physiological significance of the mitochondrial NADH kinase reaction in the absence of Ald4p is also demonstrated...
- Scientists at Sichuan University target enzyme research.
- Newspaper article from: Biotech Week September 17, 2008 700+ words
...the membrane. The cDNA sequence of Dunaliella salina mitochondrial NADH: ubiquinone oxidoreductase 19-kD subunit contains a...sequence is 74% identical to Chlamydomonas reinhardtii mitochondrial NADH:ubiquinone oxidoreductase 18-kD subunit. The 19...
- The mitochondrial cytochrome c peroxidase system of adult Hymenolepis diminuta...
- Magazine article from: The Ohio Journal of Science Green, Jahmal B. Fioravant, Carmen F. March 1, 2003 700+ words
...oxygen, it assimilates oxygen, when available, and forms [H.sup.2][O.sup.2] via a less active mitochondrial NADH oxidase system. Thus, with episodic oxygen exposure, the cestode would produce a highly reactive molecular...
- New ischemia study findings reported from Medical College of Wisconsin, Medical...
- Newspaper article from: Blood Weekly November 20, 2008 700+ words
...minutes before and for 10 minutes after 35- minute ischemia and their for 110 minutes with pH 7.4 buffer alone. Mitochondrial NADH and FAD, [Ca2+]. and superoxide were measured by spectrophotofluorometry. NADH and FAD were more oxidized...