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NEUROCHEMICAL, MOLECULAR, AND GENETIC FACTORS OF CHRONIC STRESS AND NEURONAL PATHOLOGY.
This (Scripps Research Institute) publication tests the hypothesis that chronic stress produces lasting changes in brain dopamine function, leading to permanent neuronal damage through oxidative mechanisms. Certain subject populations may be uniquely susceptible to this pathological cascade, through hyperresponsiveness of the corticotropin releasing-factor stress-response system. To test this hypothesis, two specific aims are in progress: (1) to examine the effects of chronic stress on behavioral, neurochemical, and molecular measures of neuronal pathology to the brain dopamine system; (2) to develop a phenotype of hyperresponsiveness of the CRF hypothalamic pituitary adrenal axis by selective breeding.
The results show evidence of CRF-induced hypoactivity in the brain dopamine system, as measured by an increase in ...
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