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Uncharged water-soluble, silica-absorbing polymers developed at PerkinElmer Corp. (850 Lincoln Center Dr., Foster City, CA 94404; Tel: 800/345-5224) enhance the precision of biomolecule separation in a capillary by dynamically suppressing electroendoosmotic flow and wall-analyte interactions as it is absorbed onto the surface of the capillary.
Company researchers describe the suppression as dynamic in the sense that, throughout the separation process, the polymeric medium adsorbs and desorbs in an equilibrium action. A constant degree of suppression, therefore, is maintained not only during a separation run but also from run to run. A sufficient amount of the …