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The Australian National University (Division of Immunology & Cell Biology, John Curtin School of Medical Research, Canberra ACT 0200 Australia; Tel: 61 2 6125 5111) has developed a rapid assay for detecting mammalian heparanase activity and a method for purifying heparanase with chromatographic techniques. The purified heparanase degrades both heparin and heparan sulfates, potentially useful in cancer-fighting drugs.
The university researchers were seeking a faster process for detecting heparanase activity as a step toward screening for and developing effective heparanase inhibitors. Existing heparanase assays are time consuming.
When blood-borne malignant …