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Fluoxetine modestly eases hot flashes; soy doesn't. (Results of Two Studies).
The antidepressant fluoxetine showed a modest ability to cool the intensity and frequency of hot flashes, but soy may be no better than placebo at putting out the fire, according to two recent studies.
Fluoxetine (Prozac) could reduce vasomotor symptoms in menopausal or postmenopausal patients at increased risk of breast cancer who have avoided hormone replacement therapy, investigators in the first study reported. Two groups of 81 women each with a history or increased risk of breast cancer and at least 14 hot flashes per week were randomized to receive 4 weeks of therapy with 20 mg of fluoxetine daily or placebo. They were then switched to the alternative treatment for 4 more weeks. Patients used diaries to record hot flash intensity and frequency (J. Clin. Oncol. 20[6]:1578-83, 2002).
Women on fluoxetine had significant reductions in hot flash frequency and intensity, compared with women taking placebo. The median number of daily hot flashes was 19% lower in women on fluoxetine, and the women's median hot flash scores (average daily hot flash intensity multiplied by daily frequency) were 24% lower, reported Dr. Charles L. Loprinzi of the Mayo Clinic, Rochester, Minn., and his associates.
Fluoxetine may have affected more than hot flashes: While 54% of the women reported at least mild depressive symptoms at the study's start, only 21% did so after ...
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Source: HighBeam Research, Fluoxetine modestly eases hot flashes; soy doesn't. (Results of Two...