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Women exposed in utero to the now-banned synthetic estrogen diethylstilbestrol are at increased risk of giving birth to boys with hypospadias, reported Helen Klip of the Netherlands Cancer Institute, Amsterdam, and her colleagues.
The investigators retrospectively studied 8,934 boys in the Netherlands whose mothers had previously been diagnosed with fertility problems (Lancet 359[9312]:1102-07, 2002).
Hypospadias was reported in 4 of the 205 boys born to mothers exposed to diethylstilbestrol (DES) in utero and in 8 of the 8,729 boys of unexposed ...