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No teratogenesis seen with interferon beta-1a therapy. (Data on 30 Patients with MS).
DENVER -- Unintentional pregnancies occurring during interferon beta-la therapy for multiple sclerosis do not appear to be at increased risk for teratogenesis or spontaneous abortion, Dr. Magnhild Sandberg-Wollheim reported.
These observations, which were based upon an analysis of 30 pregnancies occurring in participants in controlled clinical trials, are encouraging, but previous animal studies have linked interferon beta-la to an increase in spontaneous abortion. It therefore continues to be prudent medical practice to stop the drug when pregnancy is planned or occurs unintentionally the neurologist said at the annual meeting of the American Academy of Neurology.
Patients and their physicians can be reassured that a 9-month drug holiday is unlikely to have a significant adverse effect in patients with this chronic disease. Besides, there are some data indicating that the natural history of multiple sclerosis (MS) is one of falling relapse rates during pregnancy especially in the second and third ...
- Interferon Beta-1b Treatment Superior To Interferon Beta-1a.(for the treatment...
- Newspaper article from: Immunotherapy Weekly November 7, 2001 700+ words
...that the beneficial effects of interferon beta-1b become more pronounced over time when compared to interferon beta-1a. Professor Luca Durelli...duration of the INCOMIN study, interferon beta-1b continues and extends the...
- INDEPENDENT STUDY CONFIRMS SUPERIORITY OF INTERFERON BETA-1B OVER INTERFERON...
- Press release article from: PR Newswire October 4, 2001 700+ words
...that the beneficial effects of interferon beta-1b become more pronounced over time when compared to interferon beta-1a. Professor Luca Durelli...duration of the INCOMIN study, interferon beta-1b continues and extends the...
- Biogen Idec Announces First Patient Enrolled in the Global Phase III Study of...
- Press release article from: Business Wire June 22, 2009 700+ words
...the efficacy and safety of PEGylated interferon beta-1a (BIIB017) in patients with...determine the efficacy of PEGylated interferon beta-1a in reducing relapse rates in...Examined in Phase I studies, PEGylated interferon beta-1a was shown to be much longer acting...
- Study Shows Treatment With Interferon beta-1b Delays the Development of MS in...
- Press release article from: PR Newswire Europe September 30, 2005 700+ words
...September 30 /PRNewswire/ -- Interferon beta-1b 250 mcg(1) treatment delayed...group compared with 28 percent in the interferon beta-1b group (p< 0.0001) had...percent in the group treated with interferon beta-1b. "Treatment with interferon...
- Recurrent injection site reactions from interferon beta 1-b.(CASE REPORTS)
- Magazine article from: Journal of Drugs in Dermatology Samuel, Lena Lowenstein, Eve J. April 1, 2006 700+ words
Abstract Recombinant human interferon beta-1b is an immune-modulatory...therapeutic use of injectable interferon beta-1b are relatively common...with over a decade of use of interferon beta 1-b for MS. Given the prevalence...
- Modified interferon-beta protein may one day help multiple sclerosis patients.
- Newspaper article from: Medical Devices & Surgical Technology Week June 27, 2004 700+ words
...that a new variant of recombinant interferon-beta reduces the immunological response...protein. Administration of recombinant interferon-beta is currently the standard-of-care...of neutralizing antibodies against interferon-beta may reduce the effectiveness of this...
- Nastech Demonstrates Successful Delivery of Nasally Administered Interferon...
- Press release article from: PR Newswire March 21, 2002 700+ words
...demonstrating the successful nasal delivery of Interferon beta-1a. The Company believes that additional...invasive alternative to injectable Interferon beta. The single dose, open-label study...subject received either a 60 mcg dose of Interferon beta-1a as an intramuscular ...
- Genencor Scientists Show Reduced Immunogenicity of Modified Interferon-Beta...
- Press release article from: PR Newswire May 25, 2004 700+ words
...that a new variant of recombinant interferon-beta reduces the immunological response...protein. Administration of recombinant interferon-beta is the standard-of-care treatment...of neutralizing antibodies against interferon-beta may reduce the effectiveness of this...