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LOS ANGELES -- Singletons conceived through assisted reproductive technologies are nearly twice as likely to be born prematurely if gonadotropin stimulation is used, Dr. Amaury J. Llorens said at the annual meeting of the Society for Gynecologic Investigation.
A total of 25 of 27 observational studies in the English language medical literature of singletons conceived following assisted reproductive technologies (ART) --in vitro fertilization, gamete intrafallopian transfer, or intrauterine insemination--showed that gonadotropin stimulation was associated with a median relative risk of preterm delivery that was 90% higher than that of children whose mothers did not receive gonadotropins.
Until now, "the prevailing opinion" seems to be that gonadotropin stimulation won't affect singleton gestations, he said. Physicians may not be able to appreciate the increase in risk because both the incidence of prematurity in the general population and the chance of ongoing pregnancies after gonadotropin ...
Source: HighBeam Research, Gonadotropin use tied to prematurity in singletons conceived though...