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Aspirin and dalteparin; Thrombophilic pregnancy: use combo therapy.(Obstetrics)

OB GYN News

| March 15, 2004 | Sullivan, Michele G. | COPYRIGHT 2004 International Medical News Group. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan.  All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)Copyright

NEW ORLEANS -- Pregnant women with inherited thrombophilic disorders benefit more from a combination prophylactic regimen of aspirin and dalteparin than they do from monotherapy with either of the drugs, according to the results of a retrospective chart analysis.

Given together, aspirin and the low-molecular-weight heparin appear to potentiate each other. In the analysis, the combination reduced by 35% the probability of vascular complications resulting in growth-restricted infants, Dr. Line Leduc said in a poster presentation at the annual meeting of the Society for Maternal-Fetal Medicine.

Dr. Leduc reviewed the histories of 43 women who together had a total of 110 pregnancies. All of the women had some form of inherited thrombophilia (factor V Leiden, factor II mutation, protein S deficiency, methylenetetrahydrofolate ...

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Source: HighBeam Research, Aspirin and dalteparin; Thrombophilic pregnancy: use combo...

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