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NEW ORLEANS -- Pregnant women with inherited thrombophilic disorders benefit more from a combination prophylactic regimen of aspirin and dalteparin than they do from monotherapy with either of the drugs, according to the results of a retrospective chart analysis.
Given together, aspirin and the low-molecular-weight heparin appear to potentiate each other. In the analysis, the combination reduced by 35% the probability of vascular complications resulting in growth-restricted infants, Dr. Line Leduc said in a poster presentation at the annual meeting of the Society for Maternal-Fetal Medicine.
Dr. Leduc reviewed the histories of 43 women who together had a total of 110 pregnancies. All of the women had some form of inherited thrombophilia (factor V Leiden, factor II mutation, protein S deficiency, methylenetetrahydrofolate ...
Source: HighBeam Research, Aspirin and dalteparin; Thrombophilic pregnancy: use combo...