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Early in pregnancy: blood levels of two molecules may predict preeclampsia.(Obstetrics)
NEW ORLEANS -- Increased blood levels of soluble fms-like tyrosine kinase 1 during pregnancy and low levels of placental growth factor early in pregnancy each appear to predict development of preeclampsia, Dr. Richard Levine reported at the annual meeting of the Society for Maternal-Fetal Medicine.
The findings are a "promising lead in the pursuit of a life-threatening disorder that has defied all attempts to prevent or cure it," Dr. Duane Alexander, director of the National Institute of Child Health and Human Development (NICHD) in Bethesda, Md., said in a statement.
In a nested case-control study of 120 pairs of blood samples--1 each from a pregnant woman who developed preeclampsia and a normotensive control matched for gestational age--levels of soluble fms-like tyrosine kinase 1 (sFlt-1) were three times higher in the preeclampsia group by the time of disease onset than in controls. Levels were similar at the start of pregnancy, but slight increases were noted in the preeclampsia group beginning about 11 weeks before disease onset. The largest increases were seen 5 weeks before disease onset, said Dr. Levine of the NICHD, which sponsored the study.
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