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Framingham data: high homocysteine levels associated with hip fracture risk in the elderly.(Gynecology)
MINNEAPOLIS -- Elevated plasma levels of homocysteine correlate with a significantly increased risk of hip fractures in the elderly, Robert R. McLean reported at the annual meeting of the American Society for Bone and Mineral Research.
In a survey of 1,999 Framingham Osteoporosis Study participants, the hazard ratio for hip fracture nearly quadrupled among men in the highest quartile of plasma homocysteine concentration, compared with those in the lowest quartile. The correlation was also seen in women, but it wasn't as strong. The hazard ratio in the highest quartile was approximately double that in the lowest quartile. (See box.)
"These findings are interesting, because homocysteine concentrations can be modified by dietary intakes of B vitamins like folic acid, vitamin [B.sub.6], and vitamin [B.sub.12]," said Mr. McLean, the Framingham Osteoporosis Study field coordinator for the Hebrew Rehabilitation Center for Aged in Boston.
Based on evidence that the prevalence of osteoporosis is increased in people with homocystinuria, Mr. McLean and his associates hypothesized that high homocysteine levels may interfere with collagen crosslinking and impair bone strength. To test their hypothesis, they measured nonfasting plasma homocysteine concentrations of the participants and looked for a relationship with hip fracture risk.
The blood samples had been obtained during the study participants' 16th biennial examinations, which occurred between 1979 and 1982. The samples were frozen at the time of collection and were thawed for analysis in 1997.
A total of 825 men and 1,174 women with a mean age of 70 ...
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