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Standard therapies work, too: manipulate estrogen levels to treat hormonal headache.(Gynecology)
CANCUN, MEXICO -- Estrogen seems to exacerbate headache in women by at least two mechanisms, but the resulting hormonal headaches can be treated by standard short-term and preventive therapies in addition to manipulating levels of estradiol, according to Dr. Dawn A. Marcus.
Cycling estradiol modifies neurotransmitters, and during the course of cycling elevated estradiol protects against headache and low estradiol aggravates headache, she said at a symposium sponsored by the American Headache Society.
But estrogen itself has multifactorial and sometimes contradictory effects on headache. Increased estrogen results in increases in the headache-inhibiting neurotransmitters such as serotonin, [gamma]-aminobutyric acid (GABA), and the endorphins.
And it decreases headache-activating neurotransmitters such as dopamine and norepinephrine, said Dr. Marcus of the University of Pittsburgh.
On the other hand, increased estrogen seems to increase sensitization in the central nervous system, and this central sensitization plays a key role in current theories of migraine.
Dr. Marcus offered thoughts about several types of hormonal headaches.
In treating menstrual migraine, one must first verify the link between menses and headache activity by having women plot their headaches and their menstrual periods in diaries. Otherwise you end up treating them for a menstrual headache that doesn't get better because the headache wasn't always occurring menstrually.
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Source: HighBeam Research, Standard therapies work, too: manipulate estrogen levels to treat...