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Scientists find out what makes nicotine pleasurable _ and addictive.

Chicago Tribune (Chicago, IL)

| March 13, 2002 | COPYRIGHT 2007 Chicago Tribune. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan.  All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)Copyright

Byline: Ronald Kotulak

CHICAGO _ Working to unravel a long-standing puzzle of cigarette addiction, University of Chicago researchers have discovered why smoking is uniquely pleasurable and why nicotine has such ferociously addictive powers.

Published Thursday in the scientific journal Neuron, the research shows that nicotine not only stimulates pleasure in the brain's reward center but has the unique ability to neutralize the "off-switch" that usually throttles down good feelings quickly.

The finding provides major clues to understanding the complex process by which the brain becomes addicted to nicotine and opens new approaches to developing drugs to block nicotine's power to hijack the brain.

For the 2,000 teenagers a day who become regular smokers, the new evidence helps to explain how a single cigarette quickly teaches the brain cells of a first-time smoker…

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