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BETHESDA, MD.--Resistance to antibiotics, particularly clindamycin, is increasing among perinatal group B streptococcal infections, Dr. Paul M. Southern said at the annual conference on antimicrobial resistance sponsored by the National Foundation for Infectious Diseases.
For this reason, clindamycin may not be a suitable alternative for women who are allergic to penicillin and show colonization with group B streptococci late in pregnancy or who are at risk for the infection, said Dr. Southern, professor of pathology and infectious diseases at the University of Texas Southwestern Medical Center, Dallas.
At his institution, where there are 16,000 or more deliveries every year, all high-risk patients have received antibiotic prophylaxis before delivery for the past 8 years. Most are given ampicillin, unless they have a history of penicillin allergy and are given clindamycin instead. Similarly, the pediatrics department at the medical center has given prophylactic penicillin to all neonates over the ...