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Higher-dose estrogen patch may prevent migraine: after medical oophorectomy.(Gynecology)
CHICAGO -- Dosage maybe an important factor in the use of transdermal estradiol for prevention of headache in female migraineurs, Dr. Vincent T. Martin said at the annual meeting of the American Headache Society.
He reported new evidence from a long-term follow-up study showing that a trans dermal 100-[micro]g transdermal estradiol-17[beta] patch prevented headaches in migraineurs who had undergone medical oophorectomy. Yet a 50-[micro]g estradiol patch was not preventive, when compared with placebo.
This study is one of the first to suggest that the dosage of transdermal estradiol may play an important role in migraine prevention. If confirmed in larger-scale studies, the findings could suggest that higher doses of transdermal estrogen are required to prevent headache in premenopausal women with migraine, said Dr. Martin of the University of Cincinnati.
Currently, conflicting evidence suggests that higher doses of oral estrogen replacement therapy can both prevent and provoke headaches. In one study, a higher dose of estrogen replacement therapy was more effective in headache prevention than a lower dose (Am. J. Obstet. Gynecol. 111[2]:178-86, 1971). Others have reported a worsening of the aura (Headache 39[9]:674-78, 1999) and headache phases of migraine headaches (Cephalalgia 21[4]: 448-49, 2001) with higher doses of estrogen replacement therapy.
Evidence from a growing number of studies suggests an advantage of the transdermal estradiol patch over oral estrogen replacement therapy in the prevention of migraine.
Transdermal delivery might provide more constant estradiol levels and be less likely to provoke migraine, Dr. Martin said. More natural forms of estrogen, such as estradiol-17[beta], may be preferable to oral conjugated estrogen.
His study was a ...
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Source: HighBeam Research, Higher-dose estrogen patch may prevent migraine: after medical...