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Use Oral Desmopressin Judiciously for Nocturia.
ANAHEIM, CALIF. -- Oral desmopressin is useful in the treatment of nocturia in men and women, according to two studies presented at the annual meeting of the American Urological Association.
A third study indicated that the pathogenesis of the disorder in the elderly can be accounted for by a lower functional bladder capacity or an age-related increase in nocturnal urine volume.
Nevertheless, desmopressin should be used only after potential behavioral controls for nocturia have failed and after treatable causes of nocturia have been eliminated, said Dr. Jeffrey P. Weiss of the Urocenter of New York.
Dr. Weiss presented one of the studies, a randomized, placebo-controlled trial involving 146 men with nocturia, which was defined as awakening to void more than two times per night.
The proportion of patients with at least a 50% reduction in the number of voids per night was 34% for the desmopressin group and 3% for the placebo group.
Nocturnal urine output decreased significantly in the group receiving the drug, and the mean duration of the initial period of sleep in this group was 83 minutes longer than it was in the placebo group. Overall, 29 (35%) of the patients who received desmopressin got more than 5 hours of unbroken sleep, compared with only 1 patient (2%) in the placebo group.
Dr. Philip van Kerrebroeck of University Hospital, Maastricht, the Netherlands, reported on a similar study involving 142 women. Among women who received the drug, 46% had at least a 50% reduction in the number of voids, compared with 7% of those in the placebo group.
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Source: HighBeam Research, Use Oral Desmopressin Judiciously for Nocturia.