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Lab Thresholds Vary for Judging Aneuploidy Risk.
MAUI, HAWAII -- Laboratories nationwide may use different cutoffs for determining the results of triple-marker screening for aneuploidy--differences that can affect patient counseling.
Physicians therefore must know how each lab determines its results, Dr. Manuel Porto said at a conference on ob.gyn. ultrasound sponsored by the University of California, Irvine.
California physicians have an advantage in this respect, because all serum samples are evaluated under a common set of numerical values. Elsewhere, physicians need to pay close attention to a lab's threshold for declaring a result as normal and its rates of aneuploidy detection and false-positive results.
"In the managed care environment, you may be sending these samples to different laboratories [depending on the patient's insurer], and they may not give you the same results," said Dr. Porto, director of the division of maternal-fetal medicine and the university's Center for Fetal Evaluation.
California mandated that the triple-marker screening program be revenue-neutral, meaning ...
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Source: HighBeam Research, Lab Thresholds Vary for Judging Aneuploidy Risk.