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Genetic Testing Often Alters Treatment Decisions.
DANA POINT, CALIF. -- A positive test for BRCA1 or BRCA2. mutations frequently alters the initial treatment decisions of breast cancer patients, many of whom subsequently elect to undergo bilateral mastectomy Dr. Claudine Isaacs reported at the annual American Cancer Society science writers seminar.
In a study involving 175 women who had breast cancer but had not yet started treatment, 124 chose to be tested and 21 of those were found to carry BRCAI or BRCA2 mutations, which have been found to increase greatly the chance of a new primary breast cancer either in the contralateral or ipsilateral breast.
Before testing, 12 of the 21 women had planned to have lumpectomies. Four of those women changed their minds and chose bilateral mastectomy instead. Three women who eventually tested positive intended to have unilateral mastectomy but in the end, two chose bilateral mastectomy and one chose lumpectomy In all, 10 (43%) of the 21 women with mutations chose to undergo bilateral mastectomy said Dr. Isaacs of Georgetown University Medical Center, Washington.
Of the 51 women who declined testing, 2 of them chose bilateral mastectomy
Dr. Isaacs reported that a physician's recommendation was one of the ...
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Source: HighBeam Research, Genetic Testing Often Alters Treatment Decisions.