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Ovarian Ablation, Suppression May Aid Ca Therapy.

OB GYN News

| July 01, 2001 | FINN, ROBERT | COPYRIGHT 2001 International Medical News Group. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan.  All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)Copyright

SAN FRANCISCO -- Ovarian ablation or suppression shows promise as an adjuvant therapy in breast cancer, particularly in premenopausal women with receptor- positive lesions.

In fact, the positive effect of adjuvant chemotherapy may be due in part to chemotherapy-induced amenorrhea, Dr. Nancy E. Davidson said at the annual meeting of the American Society of Clinical Oncology.

Ovarian ablation can be achieved by oophorectomy or radiotherapy, and temporary ovarian suppression can be achieved by the use of LHRH agonists. Dr. Davidson of the Johns Hopkins Oncology Center in Baltimore reviewed a number of studies of ovarian ablation and suppression alone or with tamoxifen. These studies show an approximate one-third reduction in the rate of disease recurrence, death from breast cancer, and overall mortality.

A National Institutes of Health consensus conference last year endorsed ovarian ...

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