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Fetal Heart Rate Abnormalities Higher With Cytotec Inductions.
SAN DIEGO -- Cytotec was more effective for cervical ripening and labor induction with an unfavorable cervix than were two forms of dinoprostone, but it was associated with a higher incidence of fetal heart tracing abnormalities.
In a prospective, randomized study of 111 obstetric patients, those who received Cytotec (misoprostol) had a quicker induction of labor, averaging 24 hours from the administration of the drug until delivery, compared with 30 hours in patients who received either Cervidil or Prepidil, Dr. Patrick S. Ramsey said at the annual meeting of the Society for Obstetric Anesthesia and Perinatology.
Nevertheless, Cytotec was associated with a significantly higher incidence of fetal heart tracing abnormalities and contraction abnormalities (50%), compared with Cervidil (14%) and Prepidil (11%), said Dr. Ramsey, who conducted the study while at the Mayo Clinic in Rochester, Minn.
Cytotec is approved by the Food and Drug Administration solely for the prevention and treatment of peptic ulcers. Nevertheless, it is frequently used off label for cervical ripening and labor induction in pregnant women.
Searle, which manufactures Cytotec, sent a letter to health care providers last year reminding them not to use the drug in pregnancy.
In response, the American College of Obstetricians and Gynecologists issued a statement that Cytotec, when used appropriately, is a safe and effective agent for cervical ripening and labor induction as well as for treating serious postpartum hemorrhage.
Cervidil and Prepidil are both indicated for cervical ripening.
- Cervical ripening options produce similar results. (Three Techniques Compared).
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...for prelabor cervical ripening--intravaginal...reassuring fetal heart rate readings...3 hours for cervical ripening until the onset...strategies for cervical ripening in the third...contractions and fetal heart rate. The...
- Off-Label Use of Misoprostol Called Safe For Cervical Ripening, Induction.
- Magazine article from: OB GYN News JOHNSON, KATE February 1, 2001 700+ words
...pregnancy and as a cervical ripening/labor inducing...medical abortion and cervical ripening and labor induction...misoprostol was used for cervical ripening and labor induction...cesarean rates for fetal heart rate abnormalities...
- Oral Misoprostol Convenient, Inexpensive for Cervical Ripening.
- Magazine article from: Family Practice News BOSCHERT, SHERRY October 15, 2000 700+ words
...dinoprostone as a preinduction cervical ripening agent in an outpatient setting...tachysystole in 5, and nonreassuing fetal heart rates in 2. The insert fell...preferable to outpatient use for cervical ripening, said Dr. Tassone of the...
- Low-Dose Oral and Vaginal Misoprostol for Cervical Ripening and Labor Induction.
- Magazine article from: OB/GYN Clinical Alert August 1, 1999 700+ words
...Oral and Vaginal Misoprostol for Cervical Ripening and Labor Induction Abstract &...misoprostol given every four hours for cervical ripening. Source: Wing DA, et al. Am J...interested in oral misoprostol for cervical ripening and the induction of labor. Wing...
- Low-Dose Oral and Vaginal Misoprostol for Cervical Ripening and Labor Inducti.
- Newspaper article from: Family Practice Alert August 1, 1999 700+ words
...Oral and Vaginal Misoprostol for Cervical Ripening and Labor Induction Synopsis: A...misoprostol given every four hours for cervical ripening. Source: Wing DA, et al. Am J...interested in oral misoprostol for cervical ripening and the induction of labor. Wing...
- Link between cervical ripening and cesarean section.(Pregnancy & Birth)(Brief...
- Newspaper article from: Special Delivery September 22, 2003 700+ words
...previous vaginal delivery who receive cervical ripening before elective induction, compared...contrast, elective inductions without cervical ripening in multiparous women were not associated...through our process of preinduction cervical ripening.... We need to wait for the cervix...
- Multiparas: C-Section, cervical ripening link seen: women had previously...
- Magazine article from: OB GYN News Johnson, Kate June 15, 2003 700+ words
...previous vaginal delivery who receive cervical ripening before elective induction, compared...contrast, elective inductions without cervical ripening in multiparas were not associated...through our process of preinduction cervical ripening," he told this newspaper. "We...
- Combination helps nulliparous women: PG[E.sub.2] plus foley catheter speeds...
- Magazine article from: OB GYN News Zoler, Mitchel L. July 1, 2004 700+ words
...significantly cut the time needed for cervical ripening in nulliparous women, compared with...from a shorter time to preinduction cervical ripening and therefore a shorter overall time...Gynecologists. Two common methods for cervical ripening are treatment with an intracervical...
Source: HighBeam Research, Fetal Heart Rate Abnormalities Higher With Cytotec Inductions.