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Oral Triple-Drug Therapy.

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| June 01, 2001 | Kubetin, Sally Koch | COPYRIGHT 2001 International Medical News Group. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan.  All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)Copyright

Oral triple-drug therapy is an effective and underutilized strategy in type 2 diabetes, Dr. Diana Dills said at a meeting of the Colorado chapter of the American College of Physicians-American Society of Internal Medicine.

Here's what triple-drug therapy with metformin, a sulfonylurea, and a glitazone accomplishes, as demonstrated in a 200-patient trial in which patients on metformin and a sulfonylurea were randomized to troglitazone or placebo. After 24 weeks, the mean fasting blood glucose in the triple-drug therapy group was 43 mg/dL lower, and hemoglobin [A.sub.1c] (Hb[A.sub.1c]) was 1.3% lower than in patients on two drugs plus placebo, observed Dr. Dills, a diabetologist at the University of Colorado, Denver.

Troglitazone (Rezulin) is now off the market due to safety issues, and there are no data on triple-drug therapy using the glitazones that are now available: rosiglitazone and pioglitazone. The ...

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Source: HighBeam Research, Oral Triple-Drug Therapy.

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