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<a href="http://www.accessmylibrary.com/coms2/summary_0286-751881_ITM" title="Facts and information about Exposure to Anticonvulsant Drugs Causes Fetal Anomalies.">Exposure to Anticonvulsant Drugs Causes Fetal Anomalies.</a>
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Exposure to Anticonvulsant Drugs Causes Fetal Anomalies.
The distinctive abnormalities observed in infants of mothers who have epilepsy are caused by exposure to anticonvulsant drugs during pregnancy, not to the epilepsy itself, according to Dr. Lewis B. Holmes of Massachusetts General Hospital, Boston, and his associates.
Although the anomalies have been attributed to anticonvulsants since the 1970s, epidemiologic studies have pointed to epilepsy itself as the teratogen, and "medical textbooks have suggested that these defects are caused by other factors, such as genetic abnormalities that cause the mother's epilepsy and are inherited by the fetus," the researchers said (N. Engl. J. Med. 344[15]:1132-38, 2001).
In their study of patients seen at five maternity hospitals ...
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Source: HighBeam Research, Exposure to Anticonvulsant Drugs Causes Fetal Anomalies.