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Benefits Linger After 5 Years of Tamoxifen Therapy.
The benefits of 5 years of adjuvant tamoxifen therapy in women with operable breast cancer persist at least 15 years, but there is no additional benefit in those who take the drug for longer than 5 years, a recent study shows.
The study is an update of the Scottish Adjuvant Tamoxifen Trial, a randomized study initiated in 1978. The study compared the effects of adjuvant tamoxifen therapy taken for 5 years after mastectomy with outcomes in patients who began taking tamoxifen only if disease recurred.
A survival advantage and a decreased risk of disease recurrence were noted in the patients taking tamoxifen for 5 years.
The update of that trial included 342 patients who had used tamoxifen for 5 years and were randomly assigned to either continue or stop taking tamoxifen after being found to be disease free following ...
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...Tamoxifen Alone vs Adjuvant Tamoxifen for Operable...surgery followed by adjuvant tamoxifen in women older...daily) for 5 years or surgery followed...patients was 76 years, and the majority...surgery followed by adjuvant tamoxifen is the most appropriate...
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- Press release article from: PR Newswire December 3, 2003 700+ words
...treated for two to three years with adjuvant tamoxifen and then switched to...therapy for the full five years of primary adjuvant treatment...for a median of 2 1/2 years, and thus allows only...their recommended five-year treatment course...
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- Magazine article from: Family Practice News February 1, 2000 700+ words
...followed by chemotherapy with or without 5 years of tamoxifen. The patients were deemed...addition of tamoxifen resulted in a 5-year disease-free survival of 86%, which...receptor--negative tumors had a 5-year disease-free survival of 82% with tamoxifen...
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- Press release article from: PR Newswire October 29, 2004 700+ words
...tamoxifen therapy for five years, Novartis announced today...complete tamoxifen therapy each year will have a medical option to...treatment with tamoxifen. Even years after breast cancer diagnosis...recurrences occur more than five years after surgery. While tamoxifen...
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- Newspaper article from: Cancer Weekly December 31, 2002 700+ words
...than women between 80 and 84 years old, even after adjustment...was 0.72 for women 85-92 years old compared to women 80-84 years old, indicating that women...receive a prescription for adjuvant tamoxifen," the authors concluded...
- Switch out tamoxifen to improve ca outcomes.(Women's Health)
- Magazine article from: Family Practice News February 15, 2005 700+ words
...anastrozole (Arimidex) after 2 years of tamoxifen. He reported on...randomized to the standard 5 years of adjuvant tamoxifen or to 2 years of tamoxifen followed by 3 years of anastrozole. The 3-year rate of freedom from locoregional...
- Report summarizes breast cancer study findings from Medical University of...
- Newspaper article from: Cancer Weekly November 3, 2009 700+ words
...were treated with adjuvant tamoxifen therapy," investigators...tamoxifen for 5 years. Early relapse...cancer who received adjuvant tamoxifen for 5 years. (Clin Cancer...Patients Receiving Adjuvant Tamoxifen Therapy. Clinical...
- Study data from W. Schroth and co-authors update knowledge of breast cancer.
- Newspaper article from: Cancer Weekly November 3, 2009 700+ words
...in women receiving adjuvant tamoxifen. Retrospective analysis...patients treated with adjuvant tamoxifen for early stage breast...disease at diagnosis, adjuvant tamoxifen therapy, and no...follow-up was 6.3 years. At 9 years of follow...