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Curbing antibiotic overuse will require that physicians become better informed consumers of data from the microbiology laboratory, Dr. William J. Burman commented during an update on infectious diseases sponsored by the University of Colorado.
Positive cultures are often due to colonization rather than infection. The distinction between the two is a major confounding factor in the diagnosis of infectious diseases said Dr. Burman, who is an infectious disease specialist at the university.
Culture a specimen obtained from an unsterile site--a mucosal surface, sputum, a cutaneous ulcer--and it will nearly always be reported back as positive. But that positive culture doesn't equate to infection, he said.
And even if an infection is present, the pathogen may nor be represented in the positive culture because of inadequate ...