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Rosacea Responds Favorably to Oral Azithromycin.

OB GYN News

| May 01, 2001 | WALSH, NANCY | COPYRIGHT 2001 International Medical News Group. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan.  All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)Copyright

WASHINGTON -- Oral azithromycin produced "moderate to marked" improvement in acne rosacea patients without causing the gastrointestinal side effects typical of other macrolide antibiotics, Dr. Adolfo Fernandez-Obregon reported in a poster session at the annual meeting of the American Academy of Dermatology.

Ten patients with moderate to severe rosacea who had responded poorly to previous oral antibiotics and whose skin was sufficiently irritated to preclude topical therapy were treated with a single dosage of 250 mg of azithromycin 3 times per week. They also washed with the soap substitute Cetaphil cleanser.

All of the patients had a significant improvement in symptoms within 4 weeks, and the duration of clinical response ranged from 4 weeks to 32 weeks. "Because the period of evaluation varied from patient to patient, it was not possible to determine the minimum time required to achieve clinical remission. The duration of this observed remission also could not be determined," explained Dr. Fernandez-Obregon, who is a dermatologist in Hoboken, N.J.

No patient complained of side effects from either the azithromycin or the cleanser. Patients ...

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