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HOT SPRINGS, VA. -- ThinPrep offers a twofold improvement in the diagnosis of squamous intraepithelial lesions, compared with conventional Pap smears, a recent metaanalysis suggests.
But despite those findings, some obgyns maintain that ThinPrep should not be widely embraced until its cost-effectiveness has been demonstrated. In what is believed to be the first meta-analysis of data on the two methods, Dr. Sara Bernstein and her colleagues at the University of Virginia, Charlottesville, examined 25 studies involving more than 533,000 women. The studies were published from January 1990 through April 2000, she said at the annual meeting of the South Atlantic Association of Obstetricians and Gynecologists.
Compared with the conventional Pap smears, ThinPrep was associated with more than a twofold increase in the diagnosis of low-grade squamous intraepithelial lesions (odds ratio 2.15) and highgrade squamous intraepithelial lesions (odds ratio 2.26).
Atypical cells of undetermined significance were diagnosed at the same rate in both groups.
In all of the trials, the chance of having an adequate smear was higher in the ThinPrep groups (odds ratio 2.11).
An adequate smear was ...