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Cervical Alpha-Fetoprotein Flags Increased Risk of Preterm Birth.
RENO, NEV. -- Abnormally high maternal cervical levels of alpha-fetoprotein at 22-24 weeks' gestation were associated with an increased risk of preterm birth in a nested, case-control study presented at the annual meeting of the Society for Maternal-Fetal Medicine.
In fact, it may prove to be more useful to screen for cervical alpha-fetoprotein (APP) than for previously identified cervical markers of preterm birth "because the assay is very inexpensive, and most laboratories at major medical centers have it readily available," said study investigator Dr. Patrick Ramsey.
He and his associates hypothesized that because other cervical markers such as fetal fibronectin, ferritin, interleukin-6, and human gonadotropin have been associated with spontaneous preterm birth, abnormal levels of AFP found in cervical fluid also may be predictive of preterm birth.
The researchers drew upon data from the Preterm Prediction Study, a prospective cohort study of 2,929 women with singleton pregnancies.
The study was conducted by the Maternal-Fetal Medicine Units Network of the National Institute of Child Health and Human Development, of which Dr. Ramsey is a member.
In the Preterm Prediction Study, there were 97 cases of spontaneous preterm labor or premature rupture of the membranes for which specimens were available for APP analysis. For the current study, the investigators identified 97 controls from the same population who delivered after 37 weeks and were matched for age, race, and parity.
Median cervical AFP levels were significantly elevated in women who delivered before 32 weeks (4 ng/mL) as well as in those who delivered before 35 weeks (3.6 ng/mL). The median cervical ...
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Source: HighBeam Research, Cervical Alpha-Fetoprotein Flags Increased Risk of Preterm Birth.