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Nevirapine Doesn't Improve Standard HIV Therapy.

OB GYN News

| May 01, 2001 | DEMOTT, KATHRYN | COPYRIGHT 2001 International Medical News Group. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan.  All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)Copyright

CHICAGO -- The antiretroviral agent nevirapine doesn't provide any further reduction in the risk of perinatal HIV transmission beyond the protective effects of standard antiretroviral therapy, Dr. Alejandro Dorenbaum said at a conference on retroviruses and opportunistic infections.

In a randomized study of 1,174 HIV-infected pregnant women, there were nine cases of perinatal HIV transmission among 594 (1.5%) women who added nevirapine to standard antiretroviral therapy. Similarly, there were eight cases of transmission among 580 (1.4%) women who added a placebo to standard antiretroviral therapy. The addition of nevirapine didn't appear to make a difference in the rate of transmission even among women with particularly high viral loads and/or low CD4 cell counts, noted Dr. Dorenbaum of Chiron Corp., ...

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