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Metformin May Be Only Drug Needed for Ovulation in PCOS.
TORONTO -- Metformin is often the only drug needed to achieve ovulation and conception in patients with polycystic ovary syndrome, according to a study presented at the annual meeting of the Society for Gynecologic Investigation.
And even patients who require additional therapy with clomiphene citrate often need only small doses, said Dr. Michael Heard, a fellow in reproductive endocrinology at the Baylor College of Medicine, Houston.
"Often PCOS [polycystic ovary syndrome] patients have failed many previous attempts to get pregnant, including high doses of clomiphene citrate and in vitro fertilization. When you think of the emotional and financial cost of this, our study is good news," Dr. Heard said.
Merformin is an oral hypoglycemic drug used primarily in the treatment of diabetes. In PCOS patients, the drug has been shown to induce regular menses and ovulation; correct hyperinsulinemia, which is believed to play a role in the pathogenesis of PCOS; and reduce levels of luteinizing hormone, sex hormone --binding globulin, and ovarian androgens.
This study is one of the first to look at conception rates and time to conception for PCOS patients on metformin, he said in an interview.
A total of 49 oligomenorrheic patients with PCOS entered the study, many of them having failed multiple previous cycles on clomiphene. They were initially treated with 500 mg of metformin twice a day for a ...
- PCOS patients have increased risk of cardiovascular disease, studies show.
- Newspaper article from: OBGYN & Reproduction Week May 24, 2004 700+ words
...retrospective, cross-sectional study of 116 PCOS patients and 94 controls matched for body mass...indicator of CVD - are increased in PCOS patients. The researchers measured two forms...Tests indicated that 36.8% of PCOS patients had extremely high (above 5 mg/liter...
- Increased risk of cardiovascular disease shown in PCOS patients.
- Newspaper article from: Heart Disease Weekly June 6, 2004 700+ words
...retrospective, cross-sectional study on 116 PCOS patients and 94 BMI (body mass index)-matched...indicator of CVD - are increased in PCOS patients. The researchers measured two forms...Tests indicated that 36.8% of PCOS patients had extremely high (above 5 mg/liter...
- Increased Risk of Cardiovascular Disease Shown in PCOS Patients.
- Press release article from: PR Newswire May 5, 2004 700+ words
...retrospective, cross-sectional study on 116 PCOS patients and 94 BMI-matched controls to determine...indicator of CVD -- are increased in PCOS patients. The researchers measured two forms...Tests indicated that 36.8 percent of PCOS patients had extremely high (above 5 mg/liter...
- Screen PCOS patients' sisters, mothers for diabetes. (Higher Androgen Levels,...
- Magazine article from: OB GYN News Kirn, Timothy F. September 15, 2002 700+ words
...The second study showed that about half of the sisters of PCOS patients who actually have polycystic ovaries--and high testosterone...The researchers used ultrasound to determine whether 134 PCOS patients had polycystic ovaries. They then compared testosterone...
- Test All PCOS Patients For Thyroid Disease.(Brief Article)
- Magazine article from: Family Practice News JANCIN, BRUCE October 1, 2001 700+ words
...mL were present in 10% of controls and in 43% (25) of PCOS patients; 20 of these 25 also had an abnormal thyroid ultrasound...thyroid hormone and TSH levels, however, were normal in all PCOS patients and controls. Women are known to have a 5- to 10-fold...
- Metformin & glitazones: do they really help PCOS patients? While the use of...
- Magazine article from: Journal of Family Practice Pillai, Anush S. Bang, Heejung Green, Charles June 1, 2007 700+ words
...caused by this syndrome. Objectives Our goal was to assess the evidence for the use of TZDs or metformin in the treatment of PCOS patients. In addition, we sought to assess and compare the effectiveness of metformin vs TZDs in the clinical and biochemical regression...
- Young PCOS patients show signs of arterial aging.(polycystic ovary syndrome )
- Magazine article from: Internal Medicine News Bates, Betsy September 15, 2005 700+ words
...determined that the best predictors of endothelial damage in PCOS subjects were elevated levels of testosterone and CRP. Young PCOS patients with high levels of both should be closely followed for cardiovascular consequences of the syndrome, particularly if they...
- Young, nonobese PCOS patients have cardiac risk.(Gynecology)
- Magazine article from: OB GYN News Kirn, Timothy F. October 15, 2004 700+ words
...carotid arteries to gauge intima-media thickness, and measured flow-mediated dilation of the brachial arteries. The PCOS patients had a significantly greater mean intima-media thickness compared with controls (0.53 mm versus 0.39 mm). They also...
- Cortisol dips in PCOS patients treated for sleep apnea: study.(Gynecology)
- Magazine article from: OB GYN News Bates, Betsy October 1, 2005 700+ words
...levels at night as well as during the daytime. Obstructive sleep apnea symptoms also greatly improved in five nondiabetic PCOS patients who received continuous positive airway pressure (CPAP) for 8 weeks as part of a study presented at the annual meeting...
- Early heart disease in PCOS patients.(Clinical Capsules)(Polycystic ovary...
- Magazine article from: Family Practice News December 1, 2004 700+ words
...s carotid arteries to gauge intima-media thickness, and measured flow-mediated dilation of the brachial arteries. PCOS patients had a significantly greater mean intima-media thickness compared with controls (0.53 mm versus 0.39 mm) as well as...
Source: HighBeam Research, Metformin May Be Only Drug Needed for Ovulation in PCOS.