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Coverage for Ureaplasma urealyticum also leads to shorter hospital stays.
TORONTO -- Postcesarean endometritis can be reduced if the standard prophylactic antibiotic regimen given at the time of cesarean section were expanded to include coverage against Urea-plasma urealyticum, Dr. William Andrews reported.
In a prospective, randomized study of 597 women who underwent cesarean section, those who were given doxycycline and azithromycin in addition to standard cefotetan prophylaxis had a significantly lower incidence of postcesarean endometritis (16.9% vs. 23.9%) and a shorter hospital stay (95 hours vs. 104 hours).
"Although prophylactic antibiotics are commonly used in the U.S. [at the time of cesarean section], the antibiotic regimen rarely includes coverage for Urea-plasma urealyticum," Dr. Andrews reported in a poster presentation at the annual meeting of the Society for Gynecologic Investigation.
"It is unclear whether use of the broad-spectrum antibiotic regimen would lower the postcesarean infection rate in a hospital that already has a very low rate of such infections," Dr. Andrews said in an interview.
"However, implementation of the broader-based regimen certainly would be reasonable in a high-risk service with a high infection rate, such as tertiary obstetric care services," he said.
A theoretical drawback to the broad-spectrum approach is that it could promote bacterial resistance, resulting in an increase in ...