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Miscarriage Rate in PCOS Falls to 12% With Metformin.
Extend use throughout entire pregnancy.
ARLINGTON, VA. -- Metformin, a drug that allows women with polycystic ovary syndrome to ovulate normally and conceive, should be continued throughout their pregnancies because it also prevents miscarriage, Dr. Charles J. Glueck reported at the Clinical Research 2001 meeting.
Interim results of the ongoing study of 156 women with polycystic ovary syndrome (PCOS) who have received metformin throughout pregnancy showed 54 normal live births, 19 first trimester miscarriages, 2 tubal pregnancies, and 81 women with ongoing pregnancies that appear normal on sonography at 13 weeks or more of gestation.
"So 87% have had a favorable outcome to date, and the rate of first-trimester miscarriage has been cut to 12%--which is about the national average in 'normal' women who have no endocrine disorders," said Dr. Glueck of the cholesterol center at Jewish Hospital, Cincinnati.
In fact, in a series of 183 pregnancies at his institution in which women with PCOS were not treated with metformin, the first-trimester miscarriage rate was a striking 64%, and the live birth rate was only 35%, he said at the meeting, sponsored by the American Federation for Medical Research.
Dr. Glueck speculated that the high miscarriage rate in PCOS is probably due to high levels of plasminogen activator inhibitor, which are markedly reduced by metformin therapy.
Dr. Glueck has also done "long-distance follow-up" on a separate group of 135 pregnancies in which the women were treated with metformin at his hospital to ...
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Source: HighBeam Research, Miscarriage Rate in PCOS Falls to 12% With Metformin.