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Thiazide Helps Preserve Bone Mineral Density.
Low-dose thiazide helped preserve bone mineral density in the hip and spine among older patients in a study reported by Andrea Z. LaCroix, Ph.D, of the Group Health Cooperative of Puget Sound, Seattle, and her colleagues.
In the 3-year randomized controlled trial, they observed a positive dose-response relationship between hydrochlorothiazide treatment and changes in bone mineral density (BMD) at both the hip and spine, suggesting that low-dose therapy has potential in preventing osteoporosis.
The 309 healthy, normotensive adults (205 women, 104 men), with an average age of 68 years, received a daily dose of 12.5 mg of hydrochlorothiazide, 25 mg of hydrochlorothiazide, or a placebo (Ann. Intern. Med. 133[7]: 516-26, 2000).
At 36 months, BMD at the hip had in creased among men and women 0.48% over baseline in the 12.5-mg group and 0.61% in the 25-mg group, compared with a decline of 0.32% in the placebo group.
The effects of hydrochlorothiazide on BMD were statistically significant in the women but not in the men. After just 6 ...
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Source: HighBeam Research, Thiazide Helps Preserve Bone Mineral Density.