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Brief Estrogen Trial May Ease Mild Perimenopausal Depression.
SOUTH LAKE TAHOE, NEV. -- Perimenopausal women with mild depression deserve a trial with estrogen replacement therapy to see if it improves their mood, Dr. Vivien K. Burt said at an obstetrics and gynecology conference sponsored by the University of California, Davis.
Such a trial will either work in a matter of 3-6 weeks, or it won't. Little, if anything, is lost by giving it a try, said Dr. Burt, a psychiatrist and the director of the Women's Life Center at the University of California, Los Angeles.
"Are affective or mood changes driven by shifting hormones?" Dr. Burt asked. "We know that is true for PMS. We know that is true for post partum. We think it may be true for perimenopause, and I think hormone replacement therapy war rants a try because it doesn't take long to find out if it is going to work."
An association between severe affective symptoms and the withdrawal of systemic estrogen has not been definitively proved, Dr. Burt noted. Of the four studies that have followed groups of perimenopausal ...
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Source: HighBeam Research, Brief Estrogen Trial May Ease Mild Perimenopausal Depression.