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HRT Improves Pulmonary Function in Elderly.
Hormone replacement therapy, especially combination therapy, was associated with improved pulmonary function in a population-based, longitudinal study of more than 3,300 postmenopausal women.
Current HRT users were about 25% less likely to have pulmonary obstruction than women who either had never used HRT or were former users, after adjusting for possible confounding variables, reported Catherine L. Carlson, M.P.H, of the University of Pittsburgh and her associates in the Cardiovascular Health Study.
In addition, mean forced expiratory volume at 1 second ([FEV.sub.1]) was 9%-10% higher in current HRT users, and mean forced vital capacity (FVC) was about 8% higher (Am. J. Respir. Crit. Care Med. 163[2]:423-28, 2001).
The findings contradicted those of a recent analysis of data from the Nurses' Health Study, which showed that women who took HRT were at increased risk of developing asthma. The current findings also differed from those of two small prospective studies that tied worsening peak flow to estrogen use in women with asthma.
Women in the current study, however, were older than women in the Nurses' Health Study, with a mean age of 75 years, and had been long time users of HRT, Ms. Carlson and her associates said.
"To our knowledge, this is the first study to specifically ...
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Source: HighBeam Research, HRT Improves Pulmonary Function in Elderly.