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Occult malignancy common at oophorectomy. (Prophylactic Surgery).

OB GYN News

| May 01, 2002 | Worcester, Sharon | COPYRIGHT 2002 International Medical News Group. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan.  All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)Copyright

MIAMI BEACH -- Occult malignancy is a common finding at the time of prophylactic oophorectomy, and occult tumors are not limited to ovarian origin, according to pathologic findings in specimens from 30 women who underwent the procedure.

Furthermore, in a majority of cases the greatest dimension of the malignancy was less than 1 cm so tumors often went undetected at the time of surgery; Dr. Katherine Leeper reported at the annual meeting of the Society of Gynecologic Oncologists.

Of the 30 patients, nearly three-quarters were tested for BRCA1 and BRCA2 mutations, and 77% of those were found to have mutations. Five patients (17%) had clinically occult malignancy, four of the five were BRCA1 or BRCA2 mutation carriers, and one had not been tested, said Dr. Leeper a third year resident at the University of Washington Medical Center in Seattle.

One of the five patients with malignancy had "grossly apparent" peritoneal carcinoma at the time of laparoscopy, three had primary fallopian tube ...

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Source: HighBeam Research, Occult malignancy common at oophorectomy. (Prophylactic Surgery).

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