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Certain genes may help HRT raise HDL, cut coronary risk. (May be able to predict HRT Response).
The right genes may amplify hormone replacement therapy's ability to boost MDL cholesterol levels and could give some postmenopausal women an edge in the fight against heart disease, reported Dr. David M. Herrington and associates at Wake Forest University; Winston-Salem, N.C.
The finding could pave the way for genetic testing that better predicts HRT's effects on a woman's cardiovascular health.
The investigators measured the relationship between 10 variations of the estrogen receptor-[alpha] gene (ER-a) and the effect of HRT on MDL cholesterol levels. The researchers randomly assigned 309 postmenopausal women with established coronary artery disease to daily treatment with either 0.625 mg of estrogen, 0.625 mg of estrogen and 2.5 mg of progestin, or a placebo. The women were followed for an average of 3.2 years (N. Engl. J. Med. 346[13]:967-74, 2002).
Women with a relatively rare variation in their ER-a gene (only 18.9% of women) showed up to a 33% increase in [HDL.sub.3] cholesterol levels when treated with HRT That ...
- U.S. HHS: Cholesterol levels decline among U.S. adolescents.
- Press release article from: M2 Presswire December 8, 1998 700+ words
...8 December 1998-U.S. HHS: Cholesterol levels decline among U.S. adolescents...COMMUNICATIONS LTD3 RDATE:071298 Total cholesterol levels among U.S. adolescents declined...to the somewhat larger decrease in cholesterol levels among adults during the same time...
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...acid) in the treatment of elevated cholesterol levels. This study will evaluate the cholesterol...recommend that doctors target lower LDL cholesterol levels in their patients. Treatment with...than 40% of all Americans have LDL cholesterol levels above the currently recommended ...
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...program aimed at promoting healthy cholesterol levels today reported achieving average reductions of LDL or "bad cholesterol" levels ranging from 10% to 15% in participants with elevated cholesterol levels. Participants saw reductions within...
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...beneficial effect on cholesterol levels. In a blinded...menopausal women took P-081...period, HDL-cholesterol levels ("protective...cholesterol seen in women taking P-081...raising HDL-cholesterol levels may turn out...
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...men and 213 mg/dL in women. According to the U...for hyperlipidemia. Cholesterol levels were increased by 3...by 5.4 mg/dL in women, with a peak in January...participants who had high cholesterol levels to begin with. Overall...
- Cholesterol Levels Become Less Important With Age
- Transcript from: NPR Morning Edition November 2, 1994 700+ words
...people may not need to worry about their cholesterol levels. The study shows cholesterol levels gradually become less important over...currently take drugs to lower their cholesterol levels. A study from Yale University now...
- Predicting Cholesterol Levels: What Childhood Testing Shows
- Newspaper article from: The Washington Post Sally Squires March 14, 1989 700+ words
...which youngsters will develop high blood cholesterol levels as adults? Often they can, according...study. "The best predictor for future cholesterol levels is the childhood cholesterol levels and the amount of weight that youngsters...
- THE RELATIONSHIP OF DAILY STRESS AND HEALTH-RELATED BEHAVIORS TO ADOLESCENTS'...
- Magazine article from: Adolescence Coleman, Chris A. Friedman, Alice G. Burright, Richard G. June 22, 1998 700+ words
...a factor associated with elevated cholesterol levels in adults, this relationship has...between daily life events and total cholesterol levels among 104 high school students...children and adolescents with elevated cholesterol levels tend to maintain these elevations...
