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High TSH in Second Trimester Tied to Miscarriage.
Elevated levels of thyroid-stimulating hormone in the second trimester are associated with a fourfold increase in the rate of late fetal death, according to results of a large population-based study. The rate of late fetal death was 3.8% among 209 hypothyroid women but only 0.9% in 9,194 women without the disorder, Dr. James E. Haddow, the study's lead author, said in a telebriefing sponsored by Knoll Pharmaceutical Co., the maker of Synthroid.
The rate of late fetal death increased as TSH levels increased. "The 37 women whose TSH levels were greater than 10 mU/L had a fetal death rate of 8.1%, so there was a definite correlation between the extent of hypothyroidism and the risk of fetal death," said Dr. Haddow, medical director of the Foundation for Blood Research in Scarborough, Maine, a nonprofit medical research and education institute that helped fund the study
Hypothyroidism, defined as having a TSH level that was at least 6 mU/L, accounted for 8 of the 91 reported cases of late fetal death, according to the study (J. Med. Screen. 7[3]:127-30, 2000).
These findings follow on the heels of a 1999 retrospective study by the same group of researchers which showed that women with untreated thyroid deficiency during pregnancy were four times more likely to have children with IQ scores below 85 than women without the disorder.
"With these two bits of information-- the fetal death information from the current study and the problem of IQ lowering in the earlier study--we were very influenced in ...
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Source: HighBeam Research, High TSH in Second Trimester Tied to Miscarriage.