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Estrogen Halts Atherosclerosis in Low-Risk Women.
After 2 years of estrogen therapy, carotid wall thickness had not increased.
NEW ORLEANS -- Hormone replacement therapy halted atherosclerosis in a study of postmenopausal women who had no evidence of preexisting cardiovascular disease.
The halt in atherosclerosis would be expected to make a "big difference" in the incidence of cardiovascular events, study investigator Dr. Howard N. Hodis said in an interview. "We know that progression of atherosclerosis leads to events, and that slowing or preventing progression means fewer events.
This study is the first to assess the impact of hormone replacement therapy (HRT) for primary prevention of cardiovascular disease in postmenopausal women in a randomized, controlled setting. The results showed that daily treatment with unopposed estradiol-17[beta] halted atherosclerosis, Dr. Hodis reported at the annual scientific sessions of the American Heart Association.
This finding "should reduce the anxiety" of women and their physicians that HRT will worsen cardiovascular disease risk, he predicted.
Last year's well-publicized findings from the Heart and Estrogen/Progestin Replacement Study led to questions about the safety of HRT. The study results showed that starting estrogen plus progestin treatment in postmenopausal women with preexisting cardiovascular disease led to an immediate spike in their risk of cardiovascular events.
The new findings, from the Estrogen in the ...
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Source: HighBeam Research, Estrogen Halts Atherosclerosis in Low-Risk Women.