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HOT SPRINGS, VA. -- Magnetic resonance imaging is expensive, but it's worth it in the evaluation of obstructive mullerian anomalies such as cervical atresia and transverse and longitudinal vaginal septa, Dr. Judith Burgis said at the annual meeting of the South Atlantic Association of Obstetricians and Gynecologists.
Physicians need a high index of suspicion to diagnose mullerian anomalies, the incidence of which is thought to be between 0.1% and 3.8%.
In normal development, the mullerian ducts elongate and reach the urogenital sinus by 9 weeks' gestation. The uterovaginal canal forms and inserts into the urogenital sinus at Muller's tubercle, the ducts fuse, and internal canalization and septum resorption occur by 20 weeks' gestation. By the time the child is born, the hymen should have formed and become perforate, explained Dr. Burgis, who is in private group practice in Columbia, S.C.
With mullerian anomalies these stages of development are incomplete.
In the case of longitudinal vaginal septum, for example, there's an arrest in fetal development of the mullerian and metanephric ducts at around 8 weeks' gestation. Patients can present with or without symptoms of cyclic pain and abnormal bleeding. If the septum is incomplete, the physical exam may not show anything, making MRI highly useful for delineating the anatomy.
The goal of surgery is to excise the septum; a Foley catheter in the bladder during the procedure can help keep the anatomy defined. The vaginal mucosa behind the obstruction is mucosa-lined epithelium with glandular crypts of the cervical type. This layer has been known to eventually transform into mature squamous epithelium in 1-3 years; patients should be warned that they're likely to experience heavy discharge during this transformation period.
Dr. Burgis discussed the diagnosis and treatment of the following other mullerian anomalies:
Source: HighBeam Research, MRI Pays Off in Obstructive Mullerian Anomalies.