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BV Therapy During Pregnancy Won't Prevent STDs.
RENO, NEV. -- Treatment of asymptomatic bacterial vaginosis with metronidazole did not significantly decrease the rates of acquisition of syphilis, gonorrhea, and chlamydia during pregnancy in a study that was presented at the annual meeting of the Society for Maternal-Fetal Medicine.
The finding of abnormal vaginal flora has been associated with an increased risk of acquiring sexually transmitted diseases; restoration of normal flora has been presumed to be protective.
But in this 4-year, double-blind study, treatment of bacterial vaginosis (BV) did not prevent the development of symptomatic STDs, commented Dr. Jeanne S. Sheffield of the maternal fetal medicine unit of the National Institute of Child Health and Human Development, Bethesda, Md.
The study, presented in poster form, included 1,798 pregnant women with asymptomatic BV who were randomized to receive metronidazole (two doses of 2 g each) or placebo between 16 and 24 weeks' gestation and again between 24 and 30 weeks' gestation.
A total of 894 women ...
- Metronidazole does not reduce preterm delivery. (Asymptomatic Trich Infection).
- Magazine article from: OB GYN News Franklin, Deeanna November 1, 2001 700+ words
...placebo. Nonetheless, delivery occurred before 37 weeks' gestation significantly more often in the metronidazole group than the placebo group (19% vs. 11%). The difference was attributed primarily to an increase in preterm delivery resulting...
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- Newspaper article from: Emergency Medicine Alert November 1, 2001 700+ words
...more common in the metronidazole group. Delivery occurred...19% of women in the metronidazole group and in 10.7% in the placebo group (relative risk, 1...preterm labor in the metronidazole group (10.2% vs 3.5...
- Nabi Biopharmaceuticals presents data showing patients treated with Altastaph...
- News wire article from: Asia Africa Intelligence Wire October 7, 2005 700+ words
...bloodstream infections) and fever versus the placebo group. As previously reported, the treated...Altastaph group versus 14 days in the placebo group). This substantial reduction in the...Altastaph group versus two days in the placebo group) and fever (two days in the Altastaph...
- Nabi Biopharmaceuticals Presents Data Showing Patients Treated with Altastaph...
- Press release article from: PR Newswire October 7, 2005 700+ words
...bloodstream infections) and fever versus the placebo group. As previously reported, the treated...Altastaph group versus 14 days in the placebo group). This substantial reduction in the...Altastaph group versus two days in the placebo group) and fever (two days in the Altastaph...
- Rosuvastatin trial halted early amid fears for placebo group.
- Magazine article from: GP April 18, 2008 700+ words
...effective at lowering CVD risk. It is unsurprising the trial was stopped early because there is a need to protect those in the placebo group, added Dr Pittard. 'It is, however, scientifically correct and ethical to test a drug against a placebo rather than...
- Paion AG, of Aachen, Germany, said it is seeking a new U.S. partner for lead...
- Newspaper article from: BioWorld International November 14, 2007 700+ words
...inconclusive results reported in June from a Phase III stroke trial that yielded a greater-than-expected response in the placebo group. Paion's former partner, Forest Laboratories Inc., of New York, returned rights to the product in August. Paion later...
- Metronidazole Tied to Prematurity.
- Magazine article from: Family Practice News JOHNSON, KATE April 15, 2000 700+ words
...follow-up, 7% of women in the metronidazole group remained positive for the infection, compared with 63% in the placebo group. Overall, women on metronidazole...compared with 10.7% of the placebo group. The incidence of preterm delivery...
- Metronidazole Nearly Doubles Preterm Birth Risk.
- Magazine article from: OB GYN News JOHNSON, KATE April 1, 2000 700+ words
...follow-up, 7% of women in the metronidazole group remained positive for the infection, compared with 63% in the placebo group, Dr. Carey said. Overall...compared with 10.7% of the placebo group, he added. The incidence of...
- Journal of Urology Article Reports MacroChem Drug Induced Erection in 67-75% of...
- Press release article from: PR Newswire August 26, 1999 700+ words
LEXINGTON, Mass., Aug. 26 /PRNewswire/ -- Investigators from Northwestern University Medical School have reported in the September 1999 Journal of Urology that Topiglan(TM), a topical drug under development by MacroChem Corporation (Nasdaq: MCHM), induced erection in 67 to 75 percent of impotent
- Novel agent eases acute heart failure symptoms: dyspnea was improved in 53% of...
- Magazine article from: Family Practice News Jancin, Bruce July 1, 2008 700+ words
CHICAGO -- It's full speed ahead for a pivotal phase III clinical trial of the novel drug rolofylline in patients with acute decompensated heart failure and renal dysfunction, on the basis of its impressive performance in a 301-patient pilot study. In the preliminary round, the selective adenosine
Source: HighBeam Research, BV Therapy During Pregnancy Won't Prevent STDs.