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High-Dose Magnesium Raises Hemorrhage Risk.
Use of 'very low doses' advocated.
RENO, NEV. -- Increased maternal magnesium levels were associated with neonatal intraventricular hemorrhage among 90 women whose pregnancies were complicated by preterm labor.
Magnesium is the most commonly used tocolytic agent in the United States. Its safety and efficacy however, have never been "properly demonstrated," and-- based on the findings of this study--"the prevalence of its use should be severely curtailed," Dr. Robert Mittendorf said at the annual meeting of the Society for Maternal-Fetal Medicine.
In a poster session, Dr. Mittendorf of Loyola University Chicago, Maywood, Ill., and his colleagues presented a new analysis of data from the Magnesium and Neurologic Endpoints Trial (Mag-NET). The analysis showed that IVH was significantly associated with increased maternal magnesium serum levels among 90 mother-baby pairs.
During the course of the trial, IVH developed in 12 neonates. The mean serum level of magnesium ...
- Debate Continues on Administration of Magnesium Sulfate to Pregnant Women to...
- Newspaper article from: Life Science Weekly July 28, 2009 700+ words
...Conde-Agudelo concluded that "Antenatal magnesium sulfate should be considered for...randomized placebo-controlled trials of antenatal magnesium sulfate (MgSO4) for fetal neuroprotection...annually." The articles are: "Antenatal Magnesium Sulfate for the Prevention of Cerebral...
- Debate on administration of magnesium sulfate to pregnant women to prevent...
- Newspaper article from: NewsRx Health & Science July 19, 2009 700+ words
...Romero and Dr. Agustin Conde-Agudelo concluded that "Antenatal magnesium sulfate should be considered for use in women at high...three large, randomized placebo-controlled trials of antenatal magnesium sulfate (MgSO4) for fetal neuroprotection have recently...
- High Magnesium Dose Raises Infant Hemorrhage Risk.(Brief Article)
- Magazine article from: Family Practice News Walsh, Nancy April 1, 2001 700+ words
...no tocolysis. MagNET was a randomized trial to see if antenatal magnesium could decrease the frequency of cerebral palsy among preterm...who were exposed to high doses (greater than 48 g) of antenatal magnesium (Obstet. Gynecol. 96[2]:178-82, 2000). Despite...
- Use of Magnesium Sulfate as a Neuroprotector.(Clinical report)
- Newspaper article from: Emergency Medicine Reports August 1, 2009 700+ words
...32-0.95). This represented a check in the good column for magnesium sulfate. 5. Beneficial Effects of Antenatal Magnesium (BEAM) trial..sup.10 This was a large study conducted by the NICHD perinatal network in 2241 patients at...
- Use of Magnesium Sulfate as a Neuroprotector.
- Magazine article from: Internal Medicine Alert September 1, 2009 700+ words
...32-0.95). This represented a check in the good column for magnesium sulfate. 5. Beneficial Effects of Antenatal Magnesium (BEAM) trial..sup.10 This was a large study conducted by the NICHD perinatal network in 2241 patients at...
- Magnesium sulphate for the prevention of cerebral palsy
- Magazine article from: Inpharma Weekly Anonymous September 6, 2008 700+ words
...cerebral palsy. New England Journal of Medicine 359: 895-905, No. 9, 28 Aug 2008. 2. Stanley FJ. et al. Antenatal magnesium sulfate for neuroprotection before preterm birth? New England Journal of Medicine 359: 962-964. No. 9...
- Magnesium sulfate linked to increased TSV risk: clinical significance of...
- Magazine article from: OB GYN News MacReady, Norra November 15, 2003 700+ words
...Trial (MagNET) was designed by Dr. Robert Mittendorf of Loyola University Chicago, Maywood, to determine if antenatal magnesium sulfate could prevent adverse neonatal outcomes such as cerebral palsy and intraventricular hemorrhage. The study...
- Preterm birth: Magnesium sulphate cuts cerebral palsy risk.
- Magazine article from: Women's Health Weekly February 5, 2009 700+ words
...cells, and it improves blood flow under some circumstances. The researchers reviewed data from five trials of antenatal magnesium sulphate therapy, which together included 6,145 babies. Overall 63 women at risk of very preterm birth had...
