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Estrogen Did Not Reduce Strokes in Women at Risk.
It may have boosted the early risk of stroke and aggravated nonfatal strokes.
FORT LAUDERDALE, FLA. -- Estrogen replacement therapy did not cut the incidence of strokes in postmenopausal women with a history of cerebrovascular disease.
Moreover, results from the first prospective, controlled trial to study the impact of estrogen on secondary prevention of cerebrovascular disease suggested that estrogen may have boosted the early risk of stroke and worsened the severity of nonfatal strokes, Dr. Lawrence M. Brass reported at the 26th International Stroke Conference.
These findings were strikingly similar to the results from the Heart and Estrogen-Progestin Replacement Study (HERS), reported last year, which showed that estrogen did not cut the incidence of cardiovascular events in postmenopausal women with established atherosclerotic disease.
The current study was undertaken to test the hypothesis that estrogen replacement therapy might be able to improve lipid levels and the function of vascular endothelium. The amount of estradiol used in the trial brought women's serum levels of estrogen back up to premenopausal levels but was not high enough to trigger clot formation, he said during the conference, which was sponsored by the American Stroke Association.
The study randomized 652 postmenopausal women, ...
- Estrogen Therapy Did Not Cut Rate of Second Strokes.(Brief Article)
- Magazine article from: Family Practice News ZOLER, MITCHEL L. March 15, 2001 700+ words
...trial to study the impact of estrogen on secondary prevention of...cerebrovascular disease suggested that estrogen may have boosted the early...and worsened the severity of nonfatal strokes, Dr. Lawrence M. Brass...results from the Heart and Estrogen-Progestin Replacement Study...
- Does not protect against CHD: WHI quantifies risks, benefits of estrogen...
- Magazine article from: OB GYN News Johnson, Kate May 1, 2004 700+ words
...telephone press briefing. The estrogen-only arm of the WHI was...of nonfatal stroke among estrogen users, compared with women...translates into 12 additional nonfatal strokes per 10,000 person-years among estrogen users. An estrogen user...
- Postmenopausal Hormone Therapy and Stroke. WEST: The Women's Estrogen for...
- Magazine article from: OB/GYN Clinical Alert December 1, 2001 700+ words
...This study indicated that estrogen treatment was not effective...studies, that postmenopausal estrogen therapy reduces the risk of...placebo group. The severity of nonfatal strokes in the estradiol group was...treated group (with daily estrogen and progestin) and the placebo...
- Evista Associated With Significant Reduction in Stroke Risk For Women at High...
- Press release article from: Business Wire November 18, 2002 700+ words
...reduction in the risk of nonfatal strokes -- A 48% reduction in...data showed that combined estrogen-progestin hormone therapy...Evista, neither an estrogen nor a hormone, is a selective estrogen receptor modulator (SERM...
- The book that brought consumer advocacy to the medical system. (Barbara...
- Newspaper article from: HealthFacts September 1, 1995 700+ words
...described as natural because they combine two female hormones, estrogen and progestin. Hailed by feminists, doctors, and population...in the lungs. Blood clots to the brain caused fatal and nonfatal strokes. According to Seaman's research G.D. Searle, a major...
- Estrogen metabolism and the diet-cancer connection: rationale for assessing the...
- Magazine article from: Alternative Medicine Review Lord, Richard S. Bongiovanni, Bradley Bralley, J. Alexander April 1, 2002 700+ words
Abstract Estrogens are known for their...proliferative effects on estrogen-sensitive tissues...metabolic fates of estrogens. With this knowledge...maintain high plasma estrogen levels to treatment...to environmental estrogens can reduce cancer risk. For example, estrogen activity has ...
- ESTROGEN BENEFITS
- Newspaper article from: Post-Tribune (IN) February 7, 1995 700+ words
...women in menopause: Should they take estrogen or not? A significant new study released...long way toward settling the issue. Estrogen is clearly good for an older woman...confidence that, at the very least, estrogen reduces key cardiovascular risk factors...
- HRT, estrogen, and postmenopausal women: year-old WHI study continues to raise...
- Newspaper article from: Sports Medicine Reports Elliott, William T. July 1, 2003 700+ words
...to identify the risks or benefits of estrogen plus progesterone vs placebo in healthy...randomized to a fixed dose of conjugated estrogen 0.625 mg plus medroxyprogesterone 2...undergone hysterectomy to conjugated estrogen alone vs placebo. The combination estrogen...
Source: HighBeam Research, Estrogen Did Not Reduce Strokes in Women at Risk.