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Folic Acid Antagonists Raise the Risk of a Variety of Birth Defects.
Medications that are folic acid antagonists raise the risk not only of neural tube defects but also of cardiovascular, urinary tract, and orofacial defects, according to Dr. Sonia Hernandez-Diaz of Boston University and her associates.
One group of such agents is dihydrofolate reductase inhibitors, which block the conversion of folate to its more active metabolites. These drugs include aminopterin sulfasalazine, pyrimethamine, triamterene, trimethoprim, and methotrexate (N. Engl. J. Med. 343[22]:1608-14, 2000).
A second group acts by affecting other enzymes in folate metabolism, impairing folate absorption, or enhancing folate degradation. These agents include ...
- Maternal exposure to folic acid antagonists increases risks.
- Magazine article from: Women's Health Weekly December 18, 2008 700+ words
Exposure to folic acid antagonists during pregnancy is associated...Medical Association Journal). Folic acid antagonists include a broad range of drugs...14 982 women who had taken folic acid antagonists one year prior to delivery...
- Maternal exposure to folic acid antagonists and placenta-mediated adverse...
- Magazine article from: Canadian Medical Association. Journal Wen, Shi Wu; Zhou, Jia; Yang, Qiuying; Fraser, William; Olatunbosun, Olufemi; Walker, Mark December 2, 2008 700+ words
...studies, maternal exposure to folic acid antagonists was associated with increased...possible effects of using folic acid antagonists in pregnancy on placenta...pregnant women exposed to folic acid antagonists and women without exposure...
- Folic acid antagonists during pregnancy and the risk of birth defects.(Abstract)
- Magazine article from: Alternative Medicine Review Jurenka, Julie February 1, 2001 700+ words
Folic acid antagonists during pregnancy and the risk...associations between maternal use of folic acid antagonists and these congenital malformations...Methods: We assessed exposure to folic acid antagonists that act as dihydrofolate reductase...
- Folic Acid Antagonists during Pregnancy and the Risk of Birth Defects.(Brief...
- Magazine article from: Original Internist March 1, 2001 700+ words
...between maternal use of folic acid antagonists and these congenital malformations...We assessed exposure to folic acid antagonists that act as dihydrofolate...antiepileptic drugs. Conclusions: Folic acid antagonists, which include such common...
- Folic Acid Antagonists Raise The Risk of Birth Defects.
- Magazine article from: Family Practice News Moon, Mary Ann January 15, 2001 700+ words
Medications that are folic acid antagonists raise the risk not only of neural tube defects...22]:1608-14, 2000). A second group of folic acid antagonists acts by affecting other enzymes in folate metabolism...
- Folic acid antagonists during pregnancy and the risk of birth defects.
- Magazine article from: JAAPA-Journal of the American Academy of Physicians Assistants March 1, 2001 700+ words
...tube defects (oral clefts; cardiovascular, urinary tract, or limb-reduction defects), using two groups of folio acid antagonists. One group consisted of dihydrofolate reductase inhibitors (aminopterin, methotrexate, sulfasalazine, pyrimethamine...
- Folic acid not protective in women on AEDs: users of antiepileptics did not see...
- Magazine article from: OB GYN News Mulcahy, Nicholas August 1, 2003 700+ words
...registry were taking AEDs that are folic acid antagonists," Maya Nambisan, study coordinator...AED medications and folic acid, folic acid intake from diet, and information on other potential folic acid antagonists.
- Folic acid.(Drugs, Pregnancy And Lactation)
- Magazine article from: OB GYN News Koren, Gideon February 1, 2004 700+ words
...acid to flour is because too much folic acid may camouflage vitamin [B.sub...hematologic experts say much more folic acid is needed to camouflage pernicious...important to consider drugs that are folic acid antagonists: A large study published recently...