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For many patients with rheumatoid arthritis who also have major depression, selective serotonin reuptake inhibitors are the treatment of choice, Karen L. Smarr reported at the annual meeting of the American College of Rheumatology.
Studies conducted by Ms. Smarr and her associates revealed that 17%-27% of patients with rheumatoid arthritis also had major depression. In most of these patients, the depression developed after their rheumatoid arthritis first appeared, and it was considered secondary to their pain and functional limitations, said Ms. Smarr, a psychologist at the Veterans Affairs Medical Center in Columbia, Mo.
To assess the efficacy of drug and behavioral therapy 41 patients on a stable treatment regimen for rheumatoid arthritis were enrolled in a randomized study Fourteen patients were treated with a ...